| Bioactivity | Ph-Ph+ is a hemiprotonic compound, which is produced from phenanthroline (ph) dimerization. Ph-Ph+ has antitumor, antibacterial and antifungal activities[1]. |
| Invitro | Ph-Ph+ (0.0039-2 μmol/mL; 24-72 hours) inhibits the various tumor cell proliferation in a concentration- and time-dependent manner for H22, U251MG, human neuroblastoma SH-SY5Y cell line, mouse melanoma B16 cell line, and human lung adenocarcinoma A549 cell line). , Ph-Ph+ does not affect the viabilities of human L02 cells and HUVEC cells. Under an optical microscope, Ph-Ph+-treated tumor cells shrank and exhibited apoptotic bodies. Ph-Ph+ has a selective antitumor effect through inducing cell apoptosis[1].Ph-Ph+ has broad-spectrum antibacterial and antifungal activities, and drug-resistant bacteria, including methicillin-resistant Staphylococcus aureus[1]. |
| Name | Ph-Ph+ |
| Formula | C24H17N4+ |
| Molar Mass | 361.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |