| Bioactivity | PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respectively). PfGSK3/PfPK6-IN-2 can be used in the research of Malaria[1]. |
| Target | Plasmodium falciparum GSK3/PK6 (PfGSK3/PfPK6) |
| Invitro | PfGSK3/PfPK6-IN-2 (compound 23d) inhibits P. falciparum 3D7 load in erythrocytes (EC50: 552 nM)[1].PfGSK3/PfPK6-IN-2 (2 μM) shows cytotoxicity against HepG2 cells[1]. |
| Name | PfGSK3/PfPK6-IN-2 |
| CAS | 2797225-47-7 |
| Formula | C24H25Cl2N5OS |
| Molar Mass | 502.46 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Galal KA, et al. Identification of Novel 2,4,5-Trisubstituted Pyrimidines as Potent Dual Inhibitors of Plasmodial PfGSK3/PfPK6 with Activity against Blood Stage Parasites In Vitro. J Med Chem. 2022 Oct 13;65(19):13172-13197. |
PfGSK3/PfPK6-IN-2
CAS: 2797225-47-7 F: C24H25Cl2N5OS W: 502.46
PfGSK3/PfPK6-IN-2 is a potent dual PfGSK3/PfPK6 (Plasmodium falciparum GSK3/PK6) inhibitor (IC50: 172 nM and 11 nM respe
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This product is for research use only, not for human use. We do not sell to patients.