| Bioactivity | Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect and less pulmonary toxicity. Peplomycin induce apoptosis in oral squamous carcinoma cell line SSCKN cells and pulmonary fibrosis in rats[1][2][3][4]. |
| Invitro | Peplomycin (0-100 μM; 30 h) inhibits human oral squamous carcinoma cell line SSCKN and SCCTF cells in a dose-dependent manner[3].Peplomycin (1 μM and 10 μM; 30 h) results nuclear fragmentation and condensation of chromatin in cells dose-dependently and induces apoptosis[3].Peplomycin (5 mg/mL; 7 d) induces pulmonary fibrosis separated from saline-injected rats (N-Fib) by differentiating fibroblasts to alpha-SMA-positive MF[4]. Cell Viability Assay[3] Cell Line: |
| Name | Peplomycin |
| CAS | 68247-85-8 |
| Formula | C61H88N18O21S2 |
| Molar Mass | 1473.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Peplomycin
CAS: 68247-85-8 F: C61H88N18O21S2 W: 1473.59
Peplomycin (Bleomycin PEP; Pepleomycin) is an antibiotic analogue of Bleomycin (HY-108345), with high antitumor effect a
Data collection：peptidedb@qq.com
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