Pep63_product_DataBase

Bioactivity	Pep63 is a neuroprotective peptide (VFQVRARTVA). Pep63 has a neuroprotective effect on synaptic plasticity and memory. Pep63 can competitively bind with Aβ1-42 oligomers, and can block Aβ fiber formation. Pep63 can be used for Alzheimer’s disease (AD) research[1].
In Vivo	Pep63 可通过立体定向给药至背部海马，有效阻断 EphB2-ADDLs (Aβ 衍生的可扩散配体)的相互作用，并逆转早期 AD 小鼠模型中的记忆障碍[1]。转铁蛋白脂质体 (Transferrin-liposome) 是一种载体，可通过转铁蛋白受体 (TfR) 介导的转胞吞作用将 Pep63 递送至大脑[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1781242-18-9
Sequence	Val-Phe-Gln-Val-Arg-Ala-Arg-Thr-Val-Ala
Shortening	VFQVRARTVA
Formula	C51H87N17O13
Molar Mass	1146.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yang X, et al. Transferrin-Pep63-liposomes accelerate the clearance of Aβ and rescue impaired synaptic plasticity in early Alzheimer's disease models. Cell Death Discov. 2021 Sep 21;7(1):256.

PeptideDB