| Bioactivity | Pep2-8 is a peptide which has enhanced the antagonistic activity of proprotein convertase subtilin/ kexin 9 type (PCSK9)[1]. | ||||||
| Invitro | Pep2-8 TFA 与 C 末端截短的 PCSK9[1]结合。在 50 μM 的浓度下，Pep2-8 TFA 将 PCSK9 处理的 HepG2 细胞的 LDL 摄取恢复到对照活性的约 90%[1]。 0 --> Pep2-8 TFA 相关抗体: Cell Viability Assay[1] Cell Line: | ||||||
| Name | Pep2-8 TFA | ||||||
| Sequence | Ac-Thr-Val-Phe-Thr-Ser-Trp-Glu-Glu-Tyr-Leu-Asp-Trp-Val-NH2 | ||||||
| Shortening | Ac-TVFTSWEEYLDWV-NH2 | ||||||
| Formula | C85H111F3N16O26 | ||||||
| Molar Mass | 1715.85 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture) |
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| Reference | [1]. Lammi C, et al. Biological Characterization of Computationally Designed Analogs of peptide TVFTSWEEYLDWV (Pep2-8) with Increased PCSK9 Antagonistic Activity. Sci Rep. 2019 Feb 20;9(1):2343. |
Pep2-8 TFA
CAS: F: C85H111F3N16O26 W: 1715.85 (free base)
Pep2-8 is a peptide which has enhanced the antagonistic activity of proprotein convertase subtilin/ kexin 9 type (PCSK9)
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