Pentabromopseudilin_product_DataBase

Bioactivity	Pentabromopseudilin (PBrP) is a marine antibiotic isolated from the marine bacteria Pseudomonas bromoutilis and Alteromonas luteoviolaceus. PBrP exhibits antimicrobial, anti-tumour and phytotoxic activities. PBrP is a reversible and allosteric inhibitor of myosin Va (MyoVa). PBrP also is a potent inhibitor of transforming growth factor-β (TGF-β) activity. PBrP can be used for the research of fibrotic diseases and cancer[1].
Invitro	Pentabromopseudilin (PBrP) (0.01-1 μM, 6 h) 可防止 TGF-β 诱导的 Smad 蛋白磷酸化和核转位[1]。PBrP (0.5 μM, 6 h) 抑制 TGF-β 刺激的转录反应[1]。PBrP (0-1 μM, 6 h) 抑制 A549 细胞中 TGF-β 诱导的 EMT[1]。PBrP (0.2 μM, 20 h) 抑制 TGF-β 诱导的细胞迁移[1]。PBrP (0.01-1⟩μM, 6 h) 通过增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。PBrP (0.5μM, 0, 1, 3 h) 通过细胞膜穴样内陷增强 TβRII 的降解来阻断 TGF-β 信号传导[1]。 Western Blot Analysis[1] Cell Line:
Name	Pentabromopseudilin
CAS	10245-81-5
Formula	C10H4Br5NO
Molar Mass	553.66
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Shih-Wei W, et al. Pentabromopseudilin: a myosin V inhibitor suppresses TGF-β activity by recruiting the type II TGF-β receptor to lysosomal degradation. J Enzyme Inhib Med Chem. 2018;33(1):920-935.

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