| Bioactivity | Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flammability of materials used in different utility items. Pentabromophenol can accelerate the degradation of transforming growth factor-β (TGF-β) receptors by promoting clathrin-mediated endocytosis, thereby inhibiting the TGF-β signaling pathway. Additionally, Pentabromophenol can also induce apoptosis in peripheral blood mononuclear cells (PBMCs)[1][2]. |
| CAS | 608-71-9 |
| Formula | C6HBr5O |
| Molar Mass | 488.59 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen CL, et al. Pentabromophenol suppresses TGF-β signaling by accelerating degradation of type II TGF-β receptors via caveolae-mediated endocytosis. Sci Rep. 2017;7:43206. Published 2017 Feb 23. [2]. Barańska A, et al. Apoptosis-Inducing Potential of Selected Bromophenolic Flame Retardants 2,4,6-Tribromophenol and Pentabromophenol in Human Peripheral Blood Mononuclear Cells. Molecules. 2022 Aug 9;27(16):5056. |
Pentabromophenol
CAS: 608-71-9 F: C6HBr5O W: 488.59
Pentabromophenol (PBP) is a brominated flame retardant (BFR) widely used in various consumer products to reduce the flam
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