| Bioactivity | Penisterpenoid A (Compound 1) is a PINK1/Parkin mitochondrial autophagy signaling pathway activator, which can be isolated from the rhizosphere fungus Penicillium of the medicinal plant Bupleurum. Penicillioid A can reduce lipid accumulation and significantly improve mitochondrial function both in vitro and in vivo[1]. |
| Invitro | Penisterpenoid A (Compound 1) (20 μM, 24 h) 通过选择性激活 PINK1/Parkin 线粒体自噬信号通路在人类正常肝细胞系 LO2 中减轻脂质积累，具有降脂活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Penisterpenoid A 相关抗体: Western Blot Analysis[1]. Cell Line: |
| In Vivo | Penisterpenoid A (Compound 1) (20 μM; 72 h) 可以在非酒精性脂肪性肝病斑马鱼模型中减少脂质积累并改善线粒体功能[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C15H24O5 |
| Molar Mass | 284.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang H, et al. New sesquiterpenes and viridin derivatives from Penicillium sp. Ameliorates NAFLD by regulating the PINK1/Parkin mitophagy pathway. Bioorg Chem. 2024 Jul 16;151:107656. |