| Bioactivity | Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HFEM), HSV-2 (MS), respectively. Penciclovir shows anti-herpesvirus activity with no-toxic. Penciclovir preventes mortality in mouse[1][2]. | ||||||||||||
| Invitro | Penciclovir (0-100 µg/ml) shows anti-herpesvirus activity with EC50s of 0.5, 0.8, 2.4, 52, 100, 1.2, 1.6, 0.9, >100 µg/ml for HSV-1 (HFEM), HSV-2 (MS), VZV (Ellen), CMV (AD-169), BHV-1 (Oxford 1964), BHV-2 (New York 1), EHV-1(Quai Hals), FHV-1 (B927), SVV, respectively[1].Penciclovir (0-100 µg/ml) shows no-toxic to uninfected human cells[1]. Cell Cytotoxicity Assay[1] Cell Line: | ||||||||||||
| In Vivo | Penciclovir (100 mg/kg; s.c.; daily for 5 days) preventes mortality in mouse[2]. Animal Model: | ||||||||||||
| Name | Penciclovir | ||||||||||||
| CAS | 39809-25-1 | ||||||||||||
| Formula | C10H15N5O3 | ||||||||||||
| Molar Mass | 253.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. M.R. Boyd, et al. Penciclovir: a review of its spectrum of activity, selectivity, and cross-resistance pattern. Antiviral Chemistry and Chemotherapy, 1993, (1): 3-11. [2]. de la Fuente R, et al. The acyclic nucleoside analogue penciclovir is a potent inhibitor of equine herpesvirus type 1 (EHV-1) in tissue culture and in a murine model. Antiviral Res. 1992 May;18(1):77-89. |
Penciclovir
CAS: 39809-25-1 F: C10H15N5O3 W: 253.26
Penciclovir (VSA 671) is a potent and selective anti-herpesvirus agent with EC50 values of 0.5, 0.8 µg/ml for HSV-1 (HF
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