| Bioactivity | Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs. | |||||||||
| Invitro | Parthenolide (PTL) has a dose-dependent growth inhibition effect on NSCLC cells Calu-1, H1792, A549, H1299, H157, and H460. Parthenolide can induce cleavage of apoptotic proteins such as CASP8, CASP9, CASP3 and PARP1 both in concentration- and time-dependent manner in tested lung cancer cells, indicating that apoptosis is trigged after Parthenolide exposure. In addition to induction of apoptosis, Parthenolide also induces G0/G1 cell cycle arrest in a concentration-dependent manner in A549 cells and G2/M cell cycle arrest in H1792 cells[2]. | |||||||||
| Name | Parthenolide | |||||||||
| CAS | 20554-84-1 | |||||||||
| Formula | C15H20O3 | |||||||||
| Molar Mass | 248.32 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
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Parthenolide
CAS: 20554-84-1 F: C15H20O3 W: 248.32
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory ac
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