| Bioactivity | Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma binding sites. Panamesine is a potential atypical neuroleptic agent[1]. | ||||||||||||
| Target | IC50: 6 nM (sigma receptor) | ||||||||||||
| In Vivo | Panamesine (EMD 57445; 0.3, 1, 3, 30 mg/kg) induces a dose-dependent increase of c-fos expression in several cortical areas with the strongest signals in the piriform cortex[1]. Animal Model: | ||||||||||||
| Name | Panamesine | ||||||||||||
| CAS | 139225-22-2 | ||||||||||||
| Formula | C23H26N2O6 | ||||||||||||
| Molar Mass | 426.46 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. N Dahmen, et al. Induction of C-Fos Gene Expression by the Selective Sigma Receptor Ligand EMD 57445 in Rat Brain. Eur Neuropsychopharmacol. 1996 Aug;6(3):237-43. |
Panamesine
CAS: 139225-22-2 F: C23H26N2O6 W: 426.46
Panamesine (EMD 57445) is a sigma receptor ligand, which has a high affinity (IC50 6 nM) and selectivity for sigma bindi
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