Palmitoleoyl 3-carbacyclic phosphatidic acid_product_DataBase

Bioactivity	Palmitoleoyl 3-carbacyclic phosphatidic acid (3ccPA 16:1) is an intermediately potent inhibitor of autotaxin (ATX) with an IC50 of 620 nM. Palmitoleoyl 3-carbacyclic phosphatidic acid can be used for melanoma research[1].
Target	IC50: 620 nM (Autotaxin)
Invitro	Palmitoleoyl 3-carbacyclic phosphatidic acid (3 μM, 22 h) 显著降低 (81%) ATX 和 LPC 诱导的 A2058 细胞侵袭[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Palmitoleoyl 3-carbacyclic phosphatidic acid 相关抗体:
In Vivo	Palmitoleoyl 3-carbacyclic phosphatidic acid (250 μg/kg, 腹腔注射, 在每只小鼠静脉注射 5×105 个 B16F10 黑色素瘤细胞的 15 min 和 48 h 后注射) 与对照 (57±14 个肿瘤) 相比，阻断了 1/3 的黑色素瘤细胞肺转移 (37±10个肿瘤) [1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	910228-13-6
Formula	C20H37O5P
Molar Mass	388.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Baker DL, et al. Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasis. J Biol Chem. 2006 Aug 11;281(32):22786-93.

PeptideDB