| Bioactivity | PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b hydrochloride can be used for the research of bladder cancer research[1][2]. |
| Invitro | PZ703b hydrochloride (0-1 μM, 24 h) 与 Mivebresib 协同抑制膀胱癌细胞增殖，并通过线粒体通路诱导膀胱癌细胞凋亡[1]。PZ703b hydrochloride (0-1 μM, 48 h) 抑制 MOLT-4 和 RS4;11 的细胞活性 IC50 值分别为 15.9 和 11.3 nM[2]。PZ703b hydrochloride (10 nM, 48 h) 通过 caspase-3 介导的通路诱导 MOLT-4 细胞凋亡和 BCL-XL 的降解[2]。 Apoptosis Analysis[1] Cell Line: |
| Name | PZ703b hydrochloride |
| Formula | C80H103Cl2F3N10O11S4 |
| Molar Mass | 1636.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
PZ703b hydrochloride
CAS: F: C80H103Cl2F3N10O11S4 W: 1636.90
PZ703b hydrochloride is a Bcl-xl PROTAC degrader that induces apoptosis and inhibits cancer cell proliferation. PZ703b h
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