| Bioactivity | PV1115 is a potent and highly selective Chk2 inhibitor with an IC50 of 0.14 nM, 66000 nM, >100000 nM for Chk2, Chk1 andRSK2, respectively. PV1115 is situated within the ATP-binding pocket of Chk2[1]. |
| Target | IC50: 0.14 nM (Chk2), 66000 nM (Chk1) and >100000 nM (RSK2) |
| Name | PV1115 |
| CAS | 1093793-10-2 |
| Formula | C20H19N7O3 |
| Molar Mass | 405.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. George T Lountos,et al. Structural characterization of inhibitor complexes withcheckpoint kinase 2 (Chk2), a drug target for cancer therapy. J Struct Biol.2011 Dec;176(3):292-301. |