| Bioactivity | PU-WS13 is a selective Grp94 inhibitor, with an EC50 of 0.22 μM. | ||||||||||||
| Invitro | PU-WS13 is a Grp94 inhibitor, with an EC50 of 0.22 μM. PU-WS13 also slightly suppresses Hsp90α, Hsp90β and Trap-1, with EC50s of 27.3, 41.8 and 7.3 μM, respectively. PU-WS13 (2.5-20 μM) shows no toxicity on two nonmalignant cell lines. PU-WS13 (15 μM) disrupts the circular architecture of HER2 at the plasma membrane of SKBr3 cells mediated through Grp94. PU-WS13 inhibits Grp94, and the inhibition induces apoptosis in and reduce the viability of HER2 overexpressing breast cancer cells[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PU-WS13 相关抗体: | ||||||||||||
| CAS | 1454619-14-7 | ||||||||||||
| Formula | C17H20Cl2N6S | ||||||||||||
| Molar Mass | 411.35 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Patel PD, et al. Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nat Chem Biol. 2013 Nov;9(11):677-684. |