| Bioactivity | PTP1B-IN-20 is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B; IC50=1.05 μM) over the highly homologous T-cell protein tyrosine phosphatase (TCPTP; IC50=78.0 μM), which is a key target for type 2 diabetes inhibition[1]. |
| Target | IC50: 1.05 μM (PTP1B); 78.0 μM (TCPTP) |
| Invitro | PTP1B-IN-20 (compound 4) (0-100 μM; 15 min; 37 ℃) with 5,6-dihydroxyl groups is more potent than the positive control Na3VO4 (IC50= 2.94 μM)[1]. |
| Name | PTP1B-IN-20 |
| Formula | C26H28O15 |
| Molar Mass | 580.49 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Z, et al. Selective Inhibition of PTP1B by New Anthraquinone Glycosides from Knoxia valerianoides. J Nat Prod. 2022 Nov 18. |