PTK7/β-catenin-IN-6_product_DataBase

Bioactivity	PTK7/β-catenin-IN-6 (Compound 03653) is an inhibitor for PTK7/β-catenin interaction, which inhibits the Wnt signaling pathway, and exhibits an anticancer activity against colorectal cancer (CRC)[1].
Invitro	PTK7/β-catenin-IN-6 (25 μM) 调节与细胞增殖和迁移相关的 Wnt 信号相关基因的表达，抑制 β-catenin 转录激活并抑制 Wnt 信号通路[1]。PTK7/β-catenin-IN-6 (0-100 μM) 通过抑制 CyclinA2、CyclinE2 和 CDK 的产生将细胞周期阻滞在 G0/G1 期，抑制 HCT116、SW480 和 MEF 的增殖，IC50 分别为 20.1，19.6 和 46.3 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PTK7/β-catenin-IN-6 相关抗体: Cell Proliferation Assay[1] Cell Line:
CAS	1219439-82-3
Formula	C25H19Cl2N3O3
Molar Mass	480.34
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Ganier L, et al., Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.

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