PTK7/β-catenin-IN-1_product_DataBase

Bioactivity	PTK7/β-catenin-IN-1 (compound 01065) is a potent PTK7/β-catenin inhibitor with an IC50 of 8.9 μM and 56.5 μM for PTK7/β-catenin and p53/MDM2, respectively. PTK7/β-catenin-IN-1 has the potential for cancer research[1].
Invitro	PTK7/β-catenin-IN-1 (compound 01065；72小时) 在 HCT116、SW480 和 MEF 中具有抗增殖特性，IC50 分别为 19.6 µM、21.3 µM、41 µM[1]。PTK7/β-catenin-IN-1 (25 µM；24 小时) 增加了 S 期 HCT116 和 SW480 细胞的百分比，随后 G0/G1 期减少，表明 S 期停滞抑制细胞周期进展[1]。PTK7/β-catenin-IN-1 (25 µM；24 小时) 导致 p21 和 p27 蛋白水平显着增加[1]。PTK7/β-catenin-IN-1 (25 µM；24 小时) 导致 HCT116 和 SW480 中 AXIN2 mRNA 水平显着降低[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PTK7/β-catenin-IN-1 相关抗体: Cell Cycle Analysis[1] Cell Line:
CAS	906147-24-8
Formula	C22H16N2O2
Molar Mass	340.37
Appearance	固体
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Reference	[1]. Laetitia Ganier, et al. Discovery of Small-Molecule Inhibitors of the PTK7/β-Catenin Interaction Targeting the Wnt Signaling Pathway in Colorectal Cancer. ACS Chem Biol. 2022 May 20;17(5):1061-1072.

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