| Bioactivity | PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif[1]. | ||||||
| Target | PTBP1 | ||||||
| Name | PTBP1-RNA-binding inhibitor P6 TFA | ||||||
| Sequence | Ac-Asn-Gln-{S5}-Arg-Ala-Gln-{B5}-Ala-Leu-Gln-{R5}-Val-Asn-NH2 | ||||||
| Shortening | Ac-NQ-{S5}-RAQ-{B5}-ALQ-{R5}-VN-NH2 | ||||||
| Formula | C73H122N22O19.xC2HF3O2 | ||||||
| Molar Mass | 1597.86 (free base) | ||||||
| Appearance | 固体 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
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| Reference | [1]. Schmeing S, et al. Rationally designed stapled peptides allosterically inhibit PTBP1-RNA-binding. Chem Sci. 2023 Jul 13;14(31):8269-8278. |
PTBP1-RNA-binding inhibitor P6 TFA
CAS: F: C73H122N22O19.xC2HF3O2 W: 1597.86 (free base)
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing f
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