| Bioactivity | PT150 (ORG-34517) is a competitive and orally active glucocorticoid receptor antagonist. PT150 shows neuroprotective effects. PT150 has the potential for the research of Parkinson’s disease[1][2]. |
| In Vivo | PT150 (30, 100 mg/kg; p.o.; daily for 14 days) 对鱼藤酮 (HY-B1756) 诱发的帕金森病小鼠表现出神经保护作用[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 189035-07-2 |
| Formula | C28H30O4 |
| Molar Mass | 430.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morice C, et al. A randomized trial of safety and pharmacodynamic interactions between a selective glucocorticoid receptor antagonist, PT150, and ethanol in healthy volunteers. Sci Rep. 2021 May 10;11(1):9876. [2]. Latham AS, et al. Neuroprotective Efficacy of the Glucocorticoid Receptor Modulator PT150 in the Rotenone Mouse Model of Parkinson's Disease. bioRxiv [Preprint]. 2024 Apr 15:2024.04.12.589261. |