| Bioactivity | PSEN1-IN-2 (Compound 13K) is a PSEN1 inhibitor. PSEN1-IN-2 inhibits PSEN1-APH1A and PSEN1-APH1B complex with IC50s of 6.9 and 2.4 nM. PSEN1-IN-2 can be used for Alzheimer's disease research[1]. |
| Target | 6.9 and 2.4 nM for PSEN1-APH1A and PSEN1-APH1B complex |
| Name | PSEN1-IN-2 |
| Formula | C20H18ClFN2O3S |
| Molar Mass | 420.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Narlawar R, et al. Discovery of brain permeable 2-Azabicyclo[2.2.2]octane sulfonamides as a novel class of presenilin-1 selective γ-secretase inhibitors. Eur J Med Chem. 2023 Nov 15;260:115725. |