| Bioactivity | PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced contraction inhibition of acetylcholine (ACh)[1]. |
| Invitro | PSB-1115 (100 μM) 在回肠/空肠段中抑制 TNBS (10 mM) 诱导的 ACh 收缩抑制现象[1]。 |
| In Vivo | PSB-1115 (0.5 mg/kg; i.p.; single dose, 20 min before the inhalation) antagonizes the inhibitory effect of non-selective adenosine receptor agonist NECA (HY-103173) on mucociliary clearance in mice[2]. |
| Name | PSB-1115 |
| CAS | 152529-79-8 |
| Formula | C14H14N4O5S |
| Molar Mass | 350.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Michael S, et al. Adenosine A(2A) agonist and A(2B) antagonist mediate an inhibition of inflammation-induced contractile disturbance of a rat gastrointestinal preparation. Purinergic Signal. 2010 Mar;6(1):117-24. |
PSB-1115
CAS: 152529-79-8 F: C14H14N4O5S W: 350.35
PSB-1115 is a selective A2B Adenosine Receptor antagonist. PSB-1115 inhibits the 2,4,6-trinitrobenzenesulfonic acid (TNB
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