| Bioactivity | PS47 is an inactive E-isomer of PS48. PS48 is an activator of PDK1. PS47 can be used as a negative control for PS48[1][2]. | ||||||||||||
| Invitro | PS47 shows very low binding affinity or no binding to PDK1 (Kd>200 µM)[1]. | ||||||||||||
| Name | PS47 | ||||||||||||
| CAS | 1180676-33-8 | ||||||||||||
| Formula | C17H15ClO2 | ||||||||||||
| Molar Mass | 286.75 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Hindie V, et, al. Structure and allosteric effects of low-molecular-weight activators on the protein kinase PDK1. Nat Chem Biol. 2009 Oct;5(10):758-64. [2]. Pastor-Flores D, et, al. PIF-pocket as a target for C. albicans Pkh selective inhibitors. ACS Chem Biol. 2013 Oct 18;8(10):2283-92. |