PS121912_product_DataBase

Bioactivity	PS121912 is a selective vitamin D receptor (VDR)-coregulator inhibitor. PS121912 has acceptable metabolic stability in vivo. PS121912 can be used for the research of cancer[1].
Invitro	PS121912 在低浓度下表现得像 VDR 拮抗剂，但在高浓度下与更多靶标相互作用，导致半胱天冬酶 3/7 激活介导的细胞凋亡[1]。PS121912（与 1,25-(OH)2D3 结合）降低细胞周期蛋白 A 和 D 的转录水平，从而使 HL-60 细胞停滞在 S 期或 G2/M 期[1]。 Cell Viability Assay[1] Cell Line:
In Vivo	PS121912 表现出可接受的代谢稳定性，在体内癌症研究中可以在较高浓度下抑制代谢酶 CYP3A4[1]。
Name	PS121912
CAS	1529814-60-5
Formula	C24H21F3N2O
Molar Mass	410.43
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Sidhu PS, et al. Anticancer activity of VDR-coregulator inhibitor PS121912. Cancer Chemother Pharmacol. 2014;74(4):787-798.

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