| Bioactivity | PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inhibits activity of NF-κB by blocking IκB kinase phosphorylation in tumor-bearing rats[1]. |
| Target | IC50: 88 nM (IκB kinase-2) |
| Name | PS-1145 dihydrochloride |
| CAS | 1049743-58-9 |
| Formula | C17H13Cl3N4O |
| Molar Mass | 395.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Cernackova A, et al. Cachexia induced by Yoshida ascites hepatoma in Wistar rats is not associated with inflammatory response in the spleen or brain. J Neuroimmunol. 2019;337:577068. |
PS-1145 dihydrochloride
CAS: 1049743-58-9 F: C17H13Cl3N4O W: 395.67
PS-1145 (dihydrochloride) is a potent IκB kinase-2 inhibitor with an IC50 value of 88 nM. PS-1145 (dihydrochloride) inh
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