PRRSV/CD163-IN-1_product_DataBase

Bioactivity

PRRSV/CD163-IN-1 is a PRRSV/CD163 inhibitor. PRRSV/CD163-IN-1 can inhibit the interaction between the PRRSV glycoprotein (GP2a or GP4) and the CD163-SRCR5 domain. PRRSV/CD163-IN-1 can be used for the research of porcine reproductive and respiratory syndrome (PRRS) [1].

Invitro

PRRSV/CD163-IN-1 (Compound B7) (5 μM) 抑制 PRRSV GP4 糖蛋白和 CD163-SRCR5 结构域之间的蛋白间相互作用 (PPI)[1]。PRRSV/CD163-IN-1 (24 h) 在浓度低于 25μM 时可被 PAMs 良好耐受，LC50 值为 81.7 μM[1]。PRRSV/CD163-IN-1 (0, 5, 10, 15, or 20 μM; 4 h) 以剂量依赖性方式抑制 PRRSV 感染 PAMs[1]。PRRSV/CD163-IN-1 (15 μM) 显着抑制由 I 型和 II 型 PRRSV 菌株引起的感染[1]。 RT-PCR[1] Cell Line:

Name

PRRSV/CD163-IN-1

CAS

560995-89-3

Formula

C25H24FN5O5S2

Molar Mass

557.62

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

PeptideDB

PRRSV/CD163-IN-1

CAS: 560995-89-3 F: C25H24FN5O5S2 W: 557.62