PROTAC α-synuclein degrader 5_product_DataBase

Bioactivity	PROTAC α-synuclein degrader 5 is a highly selective small-molecule degraders (PROTAC) of α-synuclein aggregates, with an DC50 of 7.51 μM and the highest degradation rate Dmax of 89%. PROTAC α-synuclein degrader 5 contains probe molecule sery308 and E3 ligase ligands. PROTAC α-synuclein degrader 5 can be used for neurological disease research[1].
Invitro	PROTAC α-synuclein degrader 5 (Compound 2b) (0-40 μM, 48 小时) 在处理期间降低 PFF 接种的细胞模型中 α-synuclein 聚集体的水平[1]。PROTAC α-synuclein degrader 5 (0-10 μM, 48 hour) 以剂量依赖性方式降解 α-synuclein 聚集体，使 α-synuclein 阳性点的数量和密度减少以及荧光强度逐渐下降[1]。 Western Blot Analysis[1] Cell Line:
Name	PROTAC α-synuclein degrader 5
CAS	2781922-42-5
Formula	C39H41N7O10
Molar Mass	767.78
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yichen Tong, et.al. Discovery of Small-Molecule Degraders for Alpha-Synuclein Aggregates. Journal of Medicinal Chemistry 2023 66 (12), 7926-7942

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