| Bioactivity | sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH respectively. sEH-degrader-1 can effectively degrade sEH in mouse liver and brown adipose tissue (Red: Thalidomide-5-piperazine (HY-W834174), black: linker (HY-W248248), Blue: UC-1728 (HY-114266))[1]. |
| Target | IC50: 3.8 nM (hsEH). IC50=210 nM (msEH). |
| Formula | C53H65F3N8O9 |
| Molar Mass | 1015.13 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nakane K, et al. In vivo-Active Soluble Epoxide Hydrolase-targeting PROTACs with Improved Potency and Stability[J]. bioRxiv, 2024: 2024.07. 23.604814. |
PROTAC sEH-degrader-1
CAS: F: C53H65F3N8O9 W: 1015.13
sEH-degrader-1 (Compound 8) serves as an inhibitor for sEH, with IC50 values of 3.8 nM and 210 nM against hsEH and msEH
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.