| Bioactivity | PROTAC pan-IAP degrader-1 (Compound 9) is a pan-IAP degrader PROTAC. PROTAC pan-IAP degrader-1 degrades XIAP, cIAP1 and cIAP2 with DC50s of 0.7, 2.4, and 6.2 nM in MM.1S cells, respectively[1]. |
| Invitro | PROTAC pan-IAP degrader-1 (Compound 9) 以剂量依赖的方式引发 cIAP1、cIAP2 和 XIAP的降解，其 DC50 值分别为 2.4 nM、6.2 nM 和 0.7 nM[1]。PROTAC pan-IAP degrader-1 (0-10 μM; 96 h) 显著抑制癌细胞的活力[1]。 Western Blot Analysis[1] Cell Line: |
| Name | PROTAC pan-IAP degrader-1 |
| Formula | C61H82N8O9S |
| Molar Mass | 1103.42 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ng YLD, et al. Heterobifunctional Ligase Recruiters Enable pan-Degradation of Inhibitor of Apoptosis Proteins. J Med Chem. 2023 Apr 13;66(7):4703-4733. |
PROTAC pan-IAP degrader-1
CAS: F: C61H82N8O9S W: 1103.42
PROTAC pan-IAP degrader-1 (Compound 9) is a pan-IAP degrader PROTAC. PROTAC pan-IAP degrader-1 degrades XIAP, cIAP1 and
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