| Bioactivity | PROTAC VHL-type degrader-1 (compound 9b) is a VHL-type PROTAC degrader. PROTAC VHL-type degrader-1 induces ATM degradation synergistically enhancing the efficacy of ATR inhibitor AZD6738[1]. |
| CAS | 2821804-13-9 |
| Formula | C49H55N9O6S |
| Molar Mass | 898.08 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ting-Ting Liu, et al. Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors. J. Med. Chem. 2024, 67, 9, 7620–7634. |
PROTAC VHL-type degrader-1
CAS: 2821804-13-9 F: C49H55N9O6S W: 898.08
PROTAC VHL-type degrader-1 (compound 9b) is a VHL-type PROTAC degrader. PROTAC VHL-type degrader-1 induces ATM degradati
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