| Bioactivity | PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through the CRBN-dependent ubiquitin-proteasome pathway. PROTAC TRIB2 degrader-1 can inhibit cell proliferation and induce cell apoptosis, and can be used in cancer research. (Target protein ligand (Pink): HY-168275; linker (black): HY-168276; E3 Ligase Ligand-Linker Conjugates: HY-168277; E3 ligase (Blue): HY-W023573)[1]. |
| Formula | C45H45FN8O6 |
| Molar Mass | 812.89 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wen C, et al. Discovery of the First Selective and Potent PROTAC Degrader for the Pseudokinase TRIB2[J]. European Journal of Medicinal Chemistry, 2024: 117016. |
PROTAC TRIB2 degrader-1
CAS: F: C45H45FN8O6 W: 812.89
PROTAC TRIB2 degrader-1 (Compound 5k) is an effective TRIB2 degrader that selectively induces TRIB2 degradation through
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