PROTAC TG2 degrader-2_product_DataBase

Bioactivity	PROTAC TG2 degrader-2 (compound 7) is a selective, competitive degrader targeting Transglutaminase 2 (TG2), with Kd > 100 μM. PROTAC TG2 degrader-2 inhibits the cell migration and decreases the level of TG2 in ovarian cancer cells. PROTAC TG2 degrader-2 can be used for ovarian cancer study[1].
Target	> 100 μM (TG2)
Invitro	PROTAC TG2 degrader-2 (Compound 7) (10 μΜ，高达 24 h) 在伤口愈合试验侵袭迁移试验中抑制 OVCAR5 和 SKOV3 细胞系的迁移[1]。 PROTAC TG2 degrader-2 (10 μΜ) 降低 OVCAR5 和 SKOV3 细胞对纤维连接蛋白的粘附[1]。PROTAC TG2 degrader-2 (高达 10 μΜ，6 h) 在 OVCAR5 和 SKOV3 细胞中以浓度依赖的方式在 6 h 内降低谷氨酰胺转移酶 (TG2) 的水平[1]。 0 --> PROTAC TG2 degrader-2 相关抗体: Cell Migration Assay [1] Cell Line:
Name	PROTAC TG2 degrader-2
Formula	C47H57N9O6S
Molar Mass	876.08
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Valdivia A, el at. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859Valdivia A, Vagadia PP, Guo G, O'Brien E, Matei D, Schiltz GE. Discovery and Characterization of PROTACs Targeting Tissue Transglutaminase (TG2). J Med Chem. 2023;66(14):9445-9465. doi:10.1021/acs.jmedchem.2c01859

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