PROTAC STAT3 degrader-2_product_DataBase

CAS: 2429877-78-9 F: C59H60F2N9O13P W: 1172.13

PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity	PROTAC STAT3 degrader-2 is a selective and efficacious PROTAC degrader of STAT3 protein with a DC50 of 3.54 μM in Molm-16 Cell. PROTAC STAT3 degrader-2 has the potential for cancer research[1].
Invitro	PROTAC STAT3 degrader-2 (compound 27; 4 天) 在 Molm-16 具有细胞生长抑制活性，IC50 为 0.582 μM，对 SU-DHL-1 细胞作用低，IC50>10 μM[1]。PROTAC STAT3 degrader-2 在高达 5 μM 无法降低 SU-DHL-1 细胞中的 STAT3 和 pSTATSY705 蛋白水平[1]。
Name	PROTAC STAT3 degrader-2
CAS	2429877-78-9
Formula	C59H60F2N9O13P
Molar Mass	1172.13
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Haibin Zhou, et al. Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. J Med Chem. 2019 Dec 26;62(24):11280-11300.

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