| Bioactivity | PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 strongly inhibits NCI-H358 cells proliferation with an IC50 of 5 nM[1]. |
| Name | PROTAC SOS1 degrader-5 |
| CAS | 2836273-61-9 |
| Formula | C45H51F3N8O7 |
| Molar Mass | 872.93 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pang X, et al. Discovery of Potent SOS1 PROTACs with Effective Antitumor Activities against NCI-H358 Tumor Cells In Vitro/In Vivo. J Med Chem. 2024 Jan 25;67(2):1563-1579. |
PROTAC SOS1 degrader-5
CAS: 2836273-61-9 F: C45H51F3N8O7 W: 872.93
PROTAC SOS1 degrader-5 (compound 4) is a potent PROTAC SOS1 degrader, with the DC50 of 13 nM. PROTAC SOS1 degrader-5 str
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