| Bioactivity | PROTAC SOS1 degrader-1 (TFA) is a potent PROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antiproliferation activity in cancer cells with various KRAS mutations. PROTAC SOS1 degrader-1 shows antitumor effect with low toxicity[1]. |
| Target | DC50: 98.4 nM (SOS1) |
| Name | PROTAC SOS1 degrader-1 TFA |
| Formula | C59H77ClF4N10O6S |
| Molar Mass | 1165.82 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | -20°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Zhou C, et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022 Mar 10;65(5):3923-3942. |
PROTAC SOS1 degrader-1 TFA
CAS: F: C59H77ClF4N10O6S W: 1165.82
PROTAC SOS1 degrader-1 (TFA) is a potentPROTAC SOS1 degrader with an DC50 of 98.4 nM. PROTAC SOS1 degrader-1 shows antip
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