| Bioactivity | PROTAC SMARCA2/4-degrader-4 (Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 and SMARCA4. PROTAC SMARCA2/4-degrader-4 degrades SMARCA2 in MV411 and in A549 with DC50 <100 nM, degrades SMARCA4 in MV411 with DC50 <100 nM. (Pink: Ligand for target protein (HY-159472); Black: Linker (HY-159478); Blue: Ligand for E3 ligase (S,R,S)-AHPC (HY-125845))[1] |
| CAS | 2568523-81-7 |
| Formula | C56H66N10O5S |
| Molar Mass | 991.25 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ji N, et al., Smarca degraders and uses thereof. US20230072658A1. |
PROTAC SMARCA2/4-degrader-4
CAS: 2568523-81-7 F: C56H66N10O5S W: 991.25
PROTAC SMARCA2/4-degrader-4(Compound I-434) is a PROTAC degrader for catalytic subunit of the SWI/SNF complex SMARCA2 an
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