PROTAC SMARCA2/4 degrader-36_product_DataBase

Bioactivity	PROTAC SMARCA2/4 degrader-36 (Compound 29) is an effective dual degrader of SMARCA2/4, with DC50 values of 0.22 nM and 0.85 nM for SMARCA2 and SMARCA4, respectively. PROTAC SMARCA2/4 degrader-36 has anti-cell proliferation activity (Pink: Target Protein Ligand (HY-170354); Black: Linker (HY-W895794); Blue: E3 Ligase Ligand (HY-170353); E3 Ligase Ligand-Linker Conjugate (HY-170356))[1].
Target	DC50: 0.22 nM (SMARCA2). DC50: 0.85 nM (SMARCA4).
Invitro	PROTAC SMARCA2/4 degrader-36 (Compound 29) (6 天) 能抑制显著 NCIH838 和 Calu-6 细胞的增殖，其 gIC50 值分别为 3.0 nM 和 280 nM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PROTAC SMARCA2/4 degrader-36 相关抗体:
In Vivo	PROTAC SMARCA2/4 degrader-36 (Compound 29) (1-10 mg/kg; i.v.; 单剂量) 能降低小鼠肿瘤组织中的 SMARCA2 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	3033588-00-7
Formula	C53H62ClN9O4S
Molar Mass	956.64
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li Z, et al. Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders[J]. Journal of Medicinal Chemistry, 2024.

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