| Bioactivity | PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA2/4-degrader-10 has the potential for the research of cancer (Blue:SMARCA2/4 ligand, (HY-159542); Black: linker (HY-W088435); Pink:VHL ligand (HY-125845))[1]. |
| Invitro | PROTAC SMARCA2/4-degrader-10 (compound I-399) (0-1000 nM; 24 h) 诱导 MV4-11 细胞中的 SMARCA2、SMARCA4 蛋白质降解，对 SMARCA2 和 SMARCA4 的 DC50 值分别为 0 --> PROTAC SMARCA2/4-degrader-10 相关抗体: |
| CAS | 2568277-33-6 |
| Formula | C49H62N10O5S |
| Molar Mass | 903.15 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Nan Ji, et al. Smarca degraders and uses thereof. US20230072658A1. |
PROTAC SMARCA2/4-degrader-10
CAS: 2568277-33-6 F: C49H62N10O5S W: 903.15
PROTAC SMARCA2/4-degrader-10 (compound I-399) is a potent SMARCA2 degrader with an DC50 value of ＜100 nM. PROTAC SMARCA
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This product is for research use only, not for human use. We do not sell to patients.