| Bioactivity | PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for SMARCA2 with a DC50 of 1.3 nM. PROTAC SMARCA2 degrader-32 inhibits the proliferation of lung cancer cell NCI-H838 with a GI50 of 34 nM[1]. (Pink: ligand for target protein SMARCA2 ligand-11 (HY-170349); Black: linker (HY-W895794); Blue: ligand for E3 ligase VHL (HY-170348)) |
| CAS | 3033586-50-1 |
| Formula | C54H64ClN9O4S |
| Molar Mass | 970.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li Z, et al., Discovery of Potent, Highly Selective, and Efficacious SMARCA2 Degraders. J Med Chem. 2024 Nov 21. |
PROTAC SMARCA2 degrader-32
CAS: 3033586-50-1 F: C54H64ClN9O4S W: 970.66
PROTAC SMARCA2 degrader-32 (Compound 27) is the degrader for SMARCA2 with a DC50 of 1.3 nM. PROTAC SMARCA2 degrader-32 i
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