| Bioactivity | PROTAC RAF degrader 1 (compound 512) is a PROTAC RAF degrader. PROTAC RAF degrader 1 induces targeted degradation of BRAF mutants (DC50: 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). PROTAC RAF degrader 1 has anti-tumor activity. PROTAC RAF degrader 1 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF[1]. |
| Name | PROTAC RAF degrader 1 |
| CAS | 2413035-41-1 |
| Formula | C51H57F2N9O7S2 |
| Molar Mass | 1010.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Andrew P. Crew, et al. Compounds and methods for the targeted degradation of rapidly accelerated fibrosarcoma polypeptides. Patent. US 20200129627 A1. |
PROTAC RAF degrader 1
CAS: 2413035-41-1 F: C51H57F2N9O7S2 W: 1010.18
PROTAC RAF degrader 1 (compound 512) is a PROTAC RAF degrader. PROTAC RAF degrader 1 induces targeted degradation of BRA
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.