PROTAC PLK1 Degrader-1_product_DataBase

Bioactivity	PROTAC PLK1 Degrader-1 (DD-2) is a potent PROTAC PLK1 degrader. PROTAC PLK1 Degrader-1 selectively induces PLK1 degradation in cancer cells, including HeLa (DC50=2.5 μM) and nonsmall cell lung cancer (NSCLC), through the N-degron pathway[1].
Invitro	PROTAC PLK1 Degrader-1 (DD-2) (0-50 μM, 24 h) 具有显著的体外抗癌作用，可诱导 HeLa 和 NSCLC 细胞系的 G2/M 期阻滞和细胞凋亡[1]。 0 --> PROTAC PLK1 Degrader-1 相关抗体:
In Vivo	PROTAC PLK1 Degrader-1 (DD-2) (10 mg/kg，尾静脉) 在使用 HeLa 和 NSCLC 细胞系的异种移植小鼠模型中显示出显着的肿瘤生长抑制作用[1]。
Name	PROTAC PLK1 Degrader-1
Formula	C113H210N57O22P
Molar Mass	2750.27
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gunasekaran P, et al. Degradation of Polo-like Kinase 1 by the Novel Poly-Arginine N-Degron Pathway PROTAC Regulates Tumor Growth in Nonsmall Cell Lung Cancer. J Med Chem. 2023 Dec 17.

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