PROTAC PD-L1 degrader-1

CAS: F: C45H55N5O7 W: 777.95

PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTA

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Bioactivity	PROTAC PD-L1 degrader-1 is a CRBN-based PD-L1-PROTAC degrader with a notable PD-L1 protein degradation capability. PROTAC PD-L1 degrader-1 shows potent PD-L1 degradation in 4T1 cells with a DC50 of 0.609 μM. PROTAC PD-L1 degrader-1 can be used for the study of breast cancer. (Blue: CRBN ligand (HY-150839), Black: linker; Pink: PD-L inhibitor (HY-19745))[1].
Invitro	PROTAC PD-L1 degrader-1（化合物 PA8；0.078-10 μM；24 小时）对 4T1 细胞中的 PD-L1 蛋白表现出显著的降解作用，且呈剂量依赖性[1]。PROTAC PD-L1 degrader-1 与 CRBN 和 PD-L1 特异性结合，Kd 值分别为 131.77 μM 和 59.2 μM，且均呈浓度依赖性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PROTAC PD-L1 degrader-1 相关抗体: Western Blot Analysis[1] Cell Line:
In Vivo	PROTAC PD-L1 degrader-18（30-60 mg/kg；腹腔注射；每天一次，持续 15 天）可抑制 4T1 荷瘤小鼠模型中的肿瘤体积和肿瘤重量[1]。PROTAC PD-L1 degrader-1 (compound PA8) 在雄性 Sprague-Dawley 大鼠中的药代动力学参数[1]。1.19 Plasma PK properties
Formula	C45H55N5O7
Molar Mass	777.95
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hongjia Zhang, et al. Discovery of Novel Proteolysis-Targeting Chimera Molecules as Degraders of Programmed Cell Death-Ligand 1 for Breast Cancer Therapy. J Med Chem. 2024 Jun 18.