PROTAC PARP1 degrader-4

CAS: F: C51H62FN7O6S W: 920.14

PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader (DC50 in T47D and MDA-MB-231 cell lines i

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Bioactivity	PROTAC PARP1 degrader-4 (Compound 180055) is a selective PARP1 PROTAC degrader (DC50 in T47D and MDA-MB-231 cell lines is 180 nM and 240 nM, respectively). PROTAC PARP1 degrader-4 promotes ubiquitination and degradation of PARP1 as well as inhibits PARP1 enzyme activity without a noticeable DNA trapping effect. PROTAC PARP1 degrader-4 inhibits tumors carrying BRCA mutations with a minor impact on the growth of normal cells (Pink: PARP1 ligand (HY-10617A); Blue: E3 ligase VHL ligand (HY-125845); Black: linker (HY-W014787))[1].
Invitro	PROTAC PARP1 degrader-4 (1-10 μM，24-48 h) 可保护 T47D 和 MOLT4 细胞免于基因毒性诱导的细胞死亡[1]。PROTAC PARP1 degrader-4 (10 μM，3-6 天) 在 BRCA1 突变的 MOLT4 细胞中诱导细胞毒性作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> PROTAC PARP1 degrader-4 相关抗体: Cell Viability Assay[1] Cell Line:
In Vivo	PROTAC PARP1 degrader-4 (40 mg/kg，腹腔注射，16 天) 对 BRCA1 突变的 MOLT4 异种移植小鼠具有抗肿瘤作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
Formula	C51H62FN7O6S
Molar Mass	920.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen L, et al. Minimizing DNA trapping while maintaining activity inhibition via selective PARP1 degrader. Cell Death Dis. 2024 Dec 18;15(12):898.