| Bioactivity | PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is a ferroptosis inhibitor. (S,R,R)-VH032 reduces NCOA4 levels and downregulates intracellular ferrous iron (Fe2+) levels. PROTAC NCOA4 degrader-1 ameliorates liver damage in a CCl4-induced acute liver injury model[1]. |
| Formula | C62H80N10O9S |
| Molar Mass | 1141.43 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jian’ai Ji, et al. Discovery of a NCOA4 Degrader for Labile Iron-Dependent Ferroptosis Inhibition. Journal of Medicinal Chemistry 2024 67 (15), 12521-12533. |
PROTAC NCOA4 degrader-1
CAS: F: C62H80N10O9S W: 1141.43
PROTAC NCOA4 degrader-1 (Compound V3) is a PROTAC NCOA4 degrader (DC50: 3 nM in HeLa cells). PROTAC NCOA4 degrader-1 is
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This product is for research use only, not for human use. We do not sell to patients.