| Bioactivity | PROTAC JAK1 degrader 1 degrader 1 (compound 10c) is an effective and selective PROTAC JAK1 degrader with a DC50 of 214 nM. PROTAC JAK1 degrader 1 has antitumor activity. (Structure Note: PINK, JAK1 ligand 1 (HY-10961); Blue, VHL ligand Thalidomide (HY-14658); Black, linker)[1]. |
| Formula | C44H41N9O6 |
| Molar Mass | 791.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang X, et al. Discovery of a potent and selective JAK1-targeting PROTAC degrader with anti-tumor activities. Bioorg Med Chem Lett. 2024 Sep 1;109:129838. |
PROTAC JAK1 degrader 1
CAS: F: C44H41N9O6 W: 791.85
PROTAC JAK1 degrader 1 degrader 1 (compound 10c) is an effective and selective PROTAC JAK1 degrader with a DC50of 214 nM
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