| Bioactivity | PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% in K562 cells with an IC50 value of 4.87 nM ( Structural Note: Pink, IRAK4 inhibitor (HY-168611); Blue, E3 (HY-W733885); Black, linker (HY-168613))[1]. |
| CAS | 2919995-09-6 |
| Formula | C46H50ClF2N11O6 |
| Molar Mass | 926.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jinxia Ling, et al. Preparation method for naphthoisoxazole compound. WO2024199146A1 2024-10-03. |
PROTAC IRAK4 degrader-12
CAS: 2919995-09-6 F: C46H50ClF2N11O6 W: 926.41
PROTAC IRAK4 degrader-12 is a PROTAC based on Cereblon ligand, inducing a maximum degradation rate of IRAK4 of 108.46% i
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