| Bioactivity | PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand)[1]. |
| CAS | 3033829-95-4 |
| Formula | C43H45F3N8O6 |
| Molar Mass | 826.86 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Xuejūn, et al. Imidazopyridines as IRAK4 degradants and uses thereof. CN117777126A. 2024-03-29. |
PROTAC IRAK4 degrader-10
CAS: 3033829-95-4 F: C43H45F3N8O6 W: 826.86
PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of
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