| Bioactivity | PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC50 of 686 nM and a DC50 of 171 nM. PROTAC HDAC6 degrader 3 promotes the acetylation of α-tubulin[1]. (Pink: ligand for target protein (HY-171141); Blue: ligand for E3 ligase VHL (HY-150803)) |
| Formula | C46H56F2N10O9S |
| Molar Mass | 963.06 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Keuler T, et al., Development of the first non-hydroxamate selective HDAC6 degraders. Chem Commun (Camb). 2022 Oct 4;58(79):11087-11090. |
PROTAC HDAC6 degrader 3
CAS: F: C46H56F2N10O9S W: 963.06
PROTAC HDAC6 degrader 3 (Compound 4) is a selective inhibitor and degrader for HDAC6 with an IC50 of 686 nM and a DC50 o
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