| Bioactivity | PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades GSPT1 with a rate of 95% (1 μM) GSPT1 and 86% (0.1 μM). PROTAC GSPT1 degrader-1 inhibits the cell viability of HL-60 with an IC50 of 9.2 nM. (Pink: ligand for target protein (HY-W599025); Black: linker (HY-159619); Blue: ligand for E3 ligase (HY-W087383))[1] |
| CAS | 3034310-17-0 |
| Formula | C37H36ClN7O5 |
| Molar Mass | 694.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Fang Li, et al., Gspt1 degraders, compositions comprising the degrader, and methods of using the same. WO2024073871A1. |
PROTAC GSPT1 degrader-1
CAS: 3034310-17-0 F: C37H36ClN7O5 W: 694.18
PROTAC GSPT1 degrader-1 (Compound F) is a PROTAC degrader for G1 to S phase transition protein 1 (GSPT1) that degrades G
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