| Bioactivity | PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxidase 4 (GPX4), with the DC50, 48h value of 1.68 μM. PROTAC GPX4 degrader-2 induces the accumulation of lipid peroxides and mitochondrial depolarization, subsequently triggering ferroptosis. PROTAC GPX4 degrader-2 has anti-proliferative effect[1]. |
| Name | PROTAC GPX4 degrader-2 |
| Formula | C50H61ClN8O9 |
| Molar Mass | 953.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Haoze Song, et al. A potent GPX4 degrader to induce ferroptosis in HT1080 cells. Eur J Med Chem. 2023 Dec 31:265:116110. |
PROTAC GPX4 degrader-2
CAS: F: C50H61ClN8O9 W: 953.52
PROTAC GPX4 degrader-2 (compound 18a) is a proteolysis targeting chimeras (PROTACs) that can degrade glutathione peroxid
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